Main Cosmetic‑grade Ceramide Subtypes and Their Fundamental Functions
Early industry nomenclature used numerical identifiers for ceramides, while modern INCI nomenclature adopts codes such as EOP, NP, AP and NS. Correspondences exist between the old number‑based naming system and current INCI designations. The most widely‑adopted subtypes in cosmetic production are Ceramide EOP (1), NP (3), AP (6‑II) and NS (2). Their key characteristics are outlined below:
Ceramide EOP (Formerly: Ceramide 1) An acyl‑ceramide containing ω‑hydroxylated long‑chain fatty‑acid esters. Though present at relatively low levels in native human skin lipids, it plays a vital role in connecting lipid‑layer structures. Fundamental functions: Participates in lamellar‑structure assembly of the stratum corneum, helps maintain overall lipid‑layer stability, reduces transepidermal water loss, and is suitable for formulations targeting dry‑prone skin.
Ceramide NP (Formerly: Ceramide 3) The most abundant ceramide subtype in human stratum corneum and the most extensively used in cosmetic products. Fundamental functions: Contributes to the construction of stratum corneum lipid networks, forms lipid‑rich protective films on the skin surface, lowers transepidermal water loss, and relieves skin dryness and tightness. It offers broad compatibility for formulations for diverse skin types.
Ceramide AP (Formerly: Ceramide 6‑II / 7) An α‑hydroxylated ceramide involved in normal keratinocyte differentiation. Fundamental functions: Supports regular stratum corneum metabolic turnover, improves rough skin texture, maintains balanced stratum corneum conditions, and fits formulations for rough or combination skin prone to oil‑dry imbalance.
Ceramide NS (Formerly: Ceramide 2) A non‑hydroxylated ceramide, the second‑most abundant subtype within the stratum corneum. Fundamental functions: Facilitates ordered arrangement of lipid bilayers, cooperates with other ceramides to preserve stratum corneum lipid homeostasis, and is mostly applied in multi‑component compounded systems.
Supplement: Other subtypes such as Ceramide AS (5) see comparatively limited cosmetic application.
Compounding Principles for Cosmetic Manufacturing
According to the Expert Consensus on Standardized Application of Ceramides in Skin Health Management, complete solubilization represents a core prerequisite for expected performance of ceramide raw materials. Accordingly, ceramide compounding in cosmetic production requires rigorous and scientific formulation logic to avoid raw‑material precipitation and compromised performance caused by formulation defects. Industry practice generally adopts multi‑ceramide blends combined with auxiliary lipids and other moisturizing actives to mimic native stratum corneum lipid composition.
Basic Lipid Combination (Ceramides‑Cholesterol‑Free Fatty Acids)
Research confirms synergistic effects among ceramides, cholesterol and free fatty acids in native stratum corneum lipids. A reference molar ratio of approximately 3:1:1 favors formation of lamellar liquid‑crystal structures and serves as an important reference for barrier‑oriented formulations.
Ceramide blends: Prioritize Ceramide NP supplemented with EOP, AP and NS to resemble native skin lipid profiles;
Cholesterol: Enhances lipid‑layer fluidity and optimizes lipid stacking structures;
Free fatty acids: Common selections include stearic acid, behenic acid and linoleic acid, which adjust system pH and refine lipid‑bilayer architecture.
Note: The 3:1:1 value is a reference molar ratio rather than a mandatory standard. Formulators adjust ratios according to dosage form, sensory requirements and cost constraints; satisfactory performance can still be achieved outside this proportion.
Compounding Reference for Different Ceramide Subtypes
Balanced general‑purpose formulations: NP + AP + EOP. This combination supports lipid‑layer construction, moderates stratum corneum metabolism and delivers moisture retention, representing a mainstream blend for barrier‑care products.
Formulations targeting dry skin: Increase proportions of NP and EOP to strengthen lipid protective film formation.
Formulations for rough or oil‑dry imbalanced skin: Appropriately raise the proportion of AP to modulate stratum corneum metabolic conditions.
Synergistic Matching with Other Cosmetic Raw Materials
Combination with polysaccharide‑derived actives: Ceramides can be reasonably compounded with hyaluronic acid and botanical polysaccharides. The hydrophilic properties of polysaccharides improve formulation water‑holding capacity while lowering ceramide precipitation risk and enabling uniform distribution of actives within product matrices.
Combination with squalane and plant oils: Lipophilic ingredients such as squalane and jojoba oil function as solubilizers to improve dispersion stability of ceramides in water‑based formulations. They prevent particle agglomeration and phase separation and help maintain product stability throughout shelf life.
Combination with antioxidants such as Vitamin E: Enhances storage stability of ceramides within finished formulations.
Combination with panthenol: Synergistically improves skin hydration and comfort.
Key Process Considerations
Ceramides are lipophilic raw materials and require thorough melting and dispersion to avoid precipitation and crystal formation.
Recommended formulation pH is around 5.5, matching physiological skin pH.
Typical total ceramide loading in finished products ranges from 0.01‑0.5%. Performance depends heavily on compounded systems rather than simply higher concentrations.
Product Positioning and Application Directions
Based on documented physiological properties of ceramides, cosmetic products containing ceramides shall follow compliant positioning in line with cosmetic claim regulations. Permitted descriptions are limited to moisturization, sustaining stratum corneum homeostasis and alleviating dry‑rough texture. Medical‑related claims including repair, treatment, anti‑inflammation and anti‑irritation shall be avoided.
Application Scenarios
Basic moisturizing products: Applicable to daily moisturizing lotions, creams and mild essence toners. Targeting consumers with ordinary dry skin or skin prone to seasonal dryness, these products help ease dryness, tightness and flaking and maintain baseline skin hydration.
Skin‑homeostasis care products: May be incorporated into gentle care creams. For medical device post‑procedure dressings, separate regulatory registration is mandatory. Suitable for skin with unstable surface conditions susceptible to external stress, they assist in sustaining normal stratum corneum functions.
Daily maintenance skincare products: Suitable for routine skincare regimens for consumers frequently exposed to dry air or intense ultraviolet environments. Supplemental exogenous ceramides help preserve normal stratum corneum lipid levels and reduce the likelihood of skin discomfort.
Gentle skincare for infants and young children: Following rigorous safety assessment, low‑dose high‑purity ceramides can be added into infant body lotions and barrier creams. They support basic skin barrier functions for the immature skin of infants.
Conclusion
Ceramides constitute a family of structurally related sphingolipids instead of a single ingredient. NP, EOP, AP and NS are the most widely‑utilized subtypes in cosmetics, each fulfilling distinct roles within the stratum corneum lipid network. Single‑subtype ceramide usage is generally not recommended in formulation design. Blending with cholesterol, free fatty acids and moisturizing ingredients with reference to native skin lipid profiles helps achieve favorable user experience. Cosmetic products containing ceramides focus primarily on moisturization and sustaining stratum corneum lipid homeostasis. Consumers are advised to evaluate finished‑product formulations, dosage forms and individual skin conditions when selecting skincare items.
Disclaimer: This article serves as scientific material for reference only and does not constitute medical advice. Skincare outcomes are affected by complete formulation, individual skin conditions and environmental factors.
References
[1] Elias P M. Lipid barrier function of the stratum corneum [J]. Journal of Investigative Dermatology, 1983, 80 (Suppl):44 49.
[2] Pruett S T, Bushnev A, Hagedorn K, et al. Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols [J]. Journal of Lipid Research, 2008,49 (8):1621 1639.
[3] Danby S G, et al. Formulation considerations for ceramide containing moisturisers [J]. International Journal of Cosmetic Science, 2022,44 (3):287 298.
[4] 赖彦云，陶思睿，杨莉。含神经酰胺的保湿剂改善皮肤干燥的功效和安全性研究 [J]. 中国美容医学，2022,31 (02):62 66.
[5] Kim J E, Oh S J, Kang H. Ceramide containing moisturizers for skin barrier restoration: a systematic review and meta analysis [J]. Journal of the European Academy of Dermatology and Venereology,2024,38 (2):312 324.
[6] van Smeden J, Janssens M, Gooris G S, et al. The important role of stratum corneum lipids for the cutaneous barrier function [J]. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2014,1841 (3):295 313.
[7] 上海医药行业协会化妆品专业委员会神经酰胺专题研究组, 中国医药教育协会皮肤与健康教育专委会. 神经酰胺在皮肤健康管理中的规范使用专家共识[R]. 上海: ICIC 2026国际化妆品创新大会, 2026.