Acetyl Tetrapeptide-11
Acetyl Tetrapeptide-11 is a signaling cosmetic peptide. It reinforces epidermal adhesion and DEJ junction, stabilizes the basal skin connecting structure, helps firm and soothe skin, and refines skin texture. Suitable for firming and eye-care repairing formulations. Xi’an Wanlü Bio supplies high-purity powder. It is listed in the Inventory of Existing Cosmetic Ingredients in China (2021 Edition) and available in bulk supply.
Overview
What is Acetyl Tetrapeptide-11?
Acetyl Tetrapeptide-11 (abbreviated as Ac-PPYL) is an acetylated signaling peptide. It targets the DEJ (Dermal-Epidermal Junction). It upregulates Syndecan-1 proteoglycan and Collagen XVII, reinforces epidermal adhesion and basal junction, synergistically boosts collagen expression and inhibits MMP. It helps improve visible signs of sagging and fine lines and supports stable skin barrier function. It is often compounded with Acetyl Tetrapeptide-9 as Replexium, suitable for firming-focused formulations.
Note: The statements above are based on in vitro literature studies and describe the action pathway of this raw material only. This product is a cosmetic ingredient and does not represent the efficacy of finished cosmetic products. It is not a substitute for medicine and has no medical effects.
Key Parameters
Applications
Cosmetics & Skincare Applications
1. Firming & anti-wrinkle: Suitable for formulations such as firming serums, anti-wrinkle creams, eye creams and neck creams. In vitro tests show it can upregulate the expression of Collagen I, Collagen XVII and proteoglycans. It helps improve visible signs of skin sagging and fine lines, and supports skin firmness and elasticity. 2. Barrier soothing: Suitable for leave-on skincare formulations including soothing lotions and barrier repair creams. It helps maintain skin barrier condition and relieves skin discomfort such as dryness, redness and stinging sensation. 3. Daily care: Can be incorporated into lotions, day & night creams, eye serums, toner-emulsions and hydrating mask formulas to assist in keeping skin in good condition.
Product FAQ
What is Acetyl Tetrapeptide-11 and what is its mechanism of action?
Acetyl Tetrapeptide-11 (CAS: 928006-88-6) is a synthetic signaling tetrapeptide with the sequence Ac-Pro-Pro-Tyr-Leu-OH. In vitro studies identify its target at the DEJ (Dermal-Epidermal Junction). It upregulates the expression of Syndecan-1 and Collagen XVII, strengthens epidermal cell adhesion and stabilizes the basement membrane structure. It helps improve sagging and roughness associated with DEJ flattening. It is a firming peptide targeting the skin junction layer, different from peptides that merely stimulate collagen proliferation.
What is the recommended dosage of Acetyl Tetrapeptide-11?
Final dosage of pure peptide powder in finished formulations: 0.001%–0.05% (10–500 ppm). 100–300 ppm is widely used in mainstream formulas.
What are the differences between Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9 and Palmitoyl Tripeptide-1?
Acetyl Tetrapeptide-11 acts on the DEJ basement membrane and epidermal adhesion in vitro, helping improve sagging. Acetyl Tetrapeptide-9 focuses on collagen regulation in the dermal matrix. Palmitoyl Tripeptide-1 targets collagen synthesis by dermal fibroblasts. The three are often combined to synergistically act on the dermis and DEJ, ideal for developing firming formulas.
How to solve solubility issues of Acetyl Tetrapeptide-11?
It dissolves in purified water, glycerin, propylene glycol and butylene glycol. Pre-dissolve the peptide powder in polyols first, then add into the aqueous phase and stir until fully clear. For anhydrous silicone systems, pre-disperse with co-solvents.