Nonapeptide-1
Nonapeptide-1 is a cosmetic-grade signaling peptide. It competitively binds to the MC1R receptor and targets the upstream signaling pathway of melanocytes. It features good water solubility and low irritation. Suitable for skincare formulations such as serums, creams, masks and eye creams. Xi'an Wanlu can provide relevant documents and bulk supply.
Overview
What is Nonapeptide-1?
Nonapeptide-1, also known as Nonapeptide and Melitide, is a water-soluble biomimetic peptide composed of 9 amino acids. Its CAS No. is 158563-45-2, and it is included in China’s Inventory of Existing Cosmetic Ingredients (2021 Edition).
This ingredient mimics α-MSH to competitively bind to the MC1R receptor on melanocytes, acting on the upstream signaling pathway of melanin synthesis. It has low irritation. Recommended dosage in formulation: 10~500 ppm. Recommended feeding temperature: below 40°C. Compatible pH range: 4.5–7.0.
It can be applied in topical skincare products such as serums and facial masks. The finished product label for filing shall indicate "Nonapeptide-1".
Key Parameters
Applications
Application in Cosmetics & Skincare
1. Skin tone regulating skincare products: Applicable to formulations such as facial serums, lotions, creams, eye creams, facial masks, sunscreens, BB creams and foundations. This peptide competitively interferes with the binding of α-MSH to MC1R receptors and participates in the upstream signal regulation of melanocytes. It features low formulation irritation and does not damage melanocytes, making it suitable for leave-on skincare formulas requiring skin tone modulation. 2. Soothing & repairing skincare products: Thanks to its low-irritation property, it can be formulated for sensitive skin, and used in skincare formulas for post-inflammatory skin care. 3. Body care products: Can be incorporated into body care formulations including body lotions and body washes, for the development of skin tone regulating body care items.
Product FAQ
What is Nonapeptide-1 and its mechanism of action?
Nonapeptide-1 is a chemically synthesized biomimetic peptide, included in China’s Inventory of Existing Cosmetic Ingredients (2021 Edition). It competitively binds to MC1R receptors on melanocytes, acts on the upstream signaling pathway of melanin synthesis, down-regulates the expression of related proteins without damaging melanocytes.
What is the recommended dosage of Nonapeptide-1 in finished products? How to distinguish stock solution from powder?
The recommended dosage of active peptide in finished products is 10–200 ppm (0.001% ~ 0.02%). The common 1000 ppm stock solution available on the market. The 1%–4% stated in formulations refers to the addition ratio of stock solution, not the pure peptide content. Please distinguish carefully during raw material selection.
What are the differences between Nonapeptide-1, VC, Arbutin and Decapeptide-12?
Nonapeptide-1 works via upstream signal regulation; VC and Arbutin mainly act as antioxidants or tyrosinase inhibitors (downstream pathway). It can be compounded with Decapeptide-12 and Niacinamide for multi-target skincare formulation development.
What are the supply specifications of Nonapeptide-1?
Standard packages: 1g, 10g, 100g, 1kg. Custom specifications are available upon request.