Acetyl Hexapeptide-1hexapeptide-1
Acetyl Hexapeptide-1 is a biomimetic signal cosmetic peptide raw material. Please clarify your intended use and quantity before purchase. Xi'an Wanlv can supply corresponding products and supporting documentation.
Overview
What is Acetyl Hexapeptide-1?Acetyl Hexapeptide-1 (CAS: 448944-47-6) is a water-soluble synthetic hexapeptide, presented as white powder in lyophilized form. It has a different mechanism of action from Acetyl Hexapeptide-8. This raw material can mimic α-MSH and act on MC1R receptors. In vitro studies show it can activate follicular melanocyte signaling. Cell test results demonstrate its bioactivities including anti-stress, soothing, and inhibition of collagen degradation. The recommended dosage in formulation is 0.05%~0.5%. It can be applied in hair care, anti-pollution repair and anti-aging skincare formulation development. This ingredient is included in the Inventory of Existing Cosmetic Ingredients in China.
Key Parameters
Applications
Skincare Formulation Directions
1. Photodamage repair formulations: In vitro studies show it modulates melanocyte signaling and inhibits photo-induced inflammatory factors. Suitable for after-sun repair and anti-photoaging serums or creams. Not for sunscreen claims in finished products. 2. Anti-pollution repair products: Exhibits anti-stress activity at cellular level. For formulations defending against environmental stress damage and maintaining skin barrier. 3. Anti-aging & firming formulations: In vitro tests indicate inhibition of collagen degradation and supporting maintenance of matrix proteins. Applicable in serums and creams for anti-aging and photoaging repair. 4. Skin tone conditioning formulations: Modulates melanocyte signaling pathways for even skin tone development. Not a whitening raw material; no whitening claims permitted.
Haircare Formulation Directions
1. Follicle care shampoo, conditioner & hair serums: In vitro studies activate follicular melanocyte signaling for hair and scalp care formulations. Finished products shall not claim grey hair reversal or improvement of white hair. 2. Scalp soothing products: Shows in vitro scalp anti-stress activity. For formulations relieving scalp discomfort caused by external irritants.
Product FAQ
What is Acetyl Hexapeptide-1? Is it the same raw material as Acetyl Hexapeptide-8?
Acetyl Hexapeptide-1 (INCI: Acetyl Hexapeptide-1, CAS: 448944-47-6, short name: Hexapeptide-1) is a water-soluble biomimetic signal synthetic hexapeptide, appearing as white powder in lyophilized form. It is not the same raw material as Acetyl Hexapeptide-8 and they have completely different mechanisms of action. Acetyl Hexapeptide-1 targets the MC1R receptor, while Acetyl Hexapeptide-8 acts on the neuromuscular junction pathway.
What are the physicochemical parameters of Acetyl Hexapeptide-1?
Molecular weight: 870 Da; water-soluble, insoluble in oils. HPLC purity of dry powder ≥98%; recommended feeding temperature ≤45°C, applicable pH range: 4.5–7.0. Recommended addition level for skincare formulations: 0.01~0.05%; can be increased to 0.05~0.5% for haircare formulations.
What is the compliance status of Acetyl Hexapeptide-1 for cosmetics in China?
This raw material is listed in the Inventory of Existing Cosmetic Ingredients in China, classified as a conventional cosmetic ingredient.
What supply specifications are available for Acetyl Hexapeptide-1?
Standard sealed packages: 1g, 10g, 100g. Custom packaging available, with independent vial packaging for samples.
What raw materials can be used in combination with Acetyl Hexapeptide-1?
Acetyl Hexapeptide-1 is a water-soluble peptide suitable for aqueous-phase addition and can be compounded with many cosmetic active ingredients. Recommended combinations: 1. Moisturizing & barrier repair: Sodium Hyaluronate, Panthenol, Glycerin, β-Glucan. For skin barrier formulations to reduce formula irritation. 2. Antioxidation: Ergothioneine, Ferulic Acid, Vitamin C derivatives (Gentle VC derivatives such as Ascorbyl Glucoside), for environmental stress repair formulations. 3. Other signal peptides: Palmitoyl Tetrapeptide-20, Acetyl Hexapeptide-8, Biotin Tripeptide-1. Multi-pathway mechanism combination for anti-aging and scalp care complex peptide formulations. 4. Soothing ingredients: Ectoin, Dipotassium Glycyrrhizate, for formulations targeting skin stress relief and photodamage repair. Compatibility reminder: Avoid long-term coexistence with high-concentration strong acids. Feeding temperature should be controlled at ≤45°C. Formula stability and compatibility tests are recommended prior to production.