Acetyl Hexapeptide-38
Acetyl Hexapeptide-38, a plumping signal peptide. In vitro studies show it can upregulate PGC‑1α and help maintain dermal matrix structure.Xi'an Wanlv provides COA/MSDS and bulk supply.
Overview
What is Acetyl Hexapeptide-38?
Acetyl Hexapeptide-38 is a synthetic signal hexapeptide. CAS: 1400634-44-7, INCI: Acetyl Hexapeptide-38. Its in vitro mechanism is to upregulate PGC‑1α expression and facilitate skin lipid accumulation. In formulation systems, it helps visually relieve the gaunt appearance caused by skin volume loss and endows formulations with a plump visual texture for skin. In vitro studies indicate that it can assist in regulating collagen-related signals and help formulations maintain dermal structure. It is suitable for developing anti-aging formulations targeting volume loss appearance.
This product is a cosmetic-grade polypeptide raw material with good water solubility. It is compatible with serums, creams, eye care and other formulations. The recommended addition level of stock solution is 2% (0.05% active content). COA and MSDS are available; samples are supported for testing.
Key Parameters
Applications
Application in Skincare
Acetyl Hexapeptide-38 is a signal peptide for formulations targeting the appearance of volume loss. It is compatible with various aqueous and emulsified skincare formulations: 1. Contour care serums, ampoules, stock solutions; 2. Contour care creams and lotions; 3. Eye care products: eye creams, eye serums, for formulations targeting gaunt-looking eye area; 4. Lip care serums, for formulations to create a visually plump lip appearance; 5. Neck and jawline contour care formulations. Formulation Development Goals: Target the gaunt skin look and soft tissue volume loss, deliver visually plump skin, and improve fine lines caused by volume deficiency.
Product FAQ
What is Acetyl Hexapeptide-38?
Acetyl Hexapeptide-38 is a chemically synthesized acetylated hexapeptide (trade name: Adifyline), a cosmetic raw material. Its mechanism of action is to regulate lipid accumulation in preadipocytes. It is a polypeptide applicable to formulation development for contour appearance conditioning.
Is Acetyl Hexapeptide-38 the same as Acetyl Hexapeptide-8 (Argireline)?
No. Acetyl Hexapeptide-8 acts on muscle signaling pathways and is widely used in formulations for smoothing dynamic wrinkles. Acetyl Hexapeptide-38 regulates lipid metabolism in subcutaneous preadipocytes and is mainly used for formulation development targeting contour plumping. The two differ completely in amino acid sequences and targets and shall not be confused.
What is the recommended dosage of Acetyl Hexapeptide-38 in finished formulations?
The commonly supplied form on the market is 1000ppm peptide stock solution: 1–3% for serums / creams; 2–3% for lip care formulations; 1–2% for eye creams. For powder form, calculate dosage based on active peptide content. Recommended stable pH range: 5.0–6.5. It is recommended to add the material during the cooling stage (<40°C) to minimize peptide hydrolysis.
What supply specifications are available for Acetyl Hexapeptide-38?
Standard sealed packages: 1g, 10g, 100g. Custom repackaging is available upon request.