Recombinant Humanized Type Ⅲ Collagen
Recombinant Humanized Type Ⅲ Collagen, water-soluble raw material for repair and conditioning. Please specify application purpose, grade, content and quantity upon inquiry. Xi'an Wanlv can match relevant technical documents and samples.
Overview
What is Recombinant Humanized Collagen Type III?Recombinant Humanized Collagen Type III (abbreviated as RhCol-III) is produced by gene recombination technology. Specific gene fragments of human type III collagen are optimized and spliced, then transferred into engineering bacteria (such as Escherichia coli / Pichia pastoris) for expression. The collagen is prepared through fermentation, purification and other processes. The amino acid sequence of its core functional region is homologous to native human type III collagen, and it has an active triple-helix conformation.
Key Parameters
Applications
Medical & Wound Repair Field
1. Wound repair materials: This raw material can be used to prepare wound dressings (gels, sprays, compresses, etc.). After finished dressing registration, it can be applied for superficial abrasions, incisional wounds, burns, scalds and chronic wound care. The material provides cell scaffolds to support wound repair. 2. Post-aesthetic medical dressings: It can be used to prepare supporting wound dressings for phototherapy, microneedling and other aesthetic procedures. The finished dressings can assist physical protection of wounds and maintain skin barrier. 3. Post-operative care materials: Applicable for preparing post-operative physical wound dressings, providing physical protective scaffolds to support tissue repair.
Medical Aesthetics & Anti-Aging Field
1. Dermal soft tissue repair devices: The raw material can be used to prepare injectable collagen matrix products. After medical device registration, it can be applied for dermal soft tissue reconstruction and facial soft tissue repair. 2. Post-aesthetic repair dressings: Used as raw material for supporting repair dressings in aesthetic procedures. Finished dressings help maintain skin barrier after aesthetic treatments. 3. Barrier repair dressing raw material: Can be used to prepare skin barrier repair dressings for physical care of barrier-damaged skin. Note: Products for soft tissue filling are only available for Class III medical devices with valid registration certificates.
Skincare & Daily Skin Care Field
Can be added as an active raw material into serums, masks, creams and other skincare formulations for skin barrier maintenance formula development. The efficacy claims of final skincare products shall be completed with efficacy evaluation and filing by brands in accordance with cosmetic regulations.
Tissue Engineering & Regenerative Medicine Field
1. Bone tissue engineering scaffolds: This raw material can be compounded with hydrogels and other materials to manufacture bone repair scaffolds. Finished scaffolds support osteocyte adhesion, proliferation and differentiation. 2. Soft tissue engineering: Can be used as cell scaffold raw material for 3D bioprinting, constructing soft tissue regeneration scaffolds to assist soft tissue repair research. 3. Cardiovascular biomaterials: Can serve as raw material for vascular stent coatings and tissue engineering scaffolds, supporting endothelial cell adhesion and growth and improving the biocompatibility of scaffold materials.
Product FAQ
What is Recombinant Type III Humanized Collagen?
Recombinant Type III Humanized Collagen (RhCol‑III) is a Type A functional collagen raw material manufactured by gene recombination and synthetic biology technologies. Specific gene fragments of human Type III collagen are optimized and spliced, then expressed in engineering bacteria and produced via fermentation and purification. Its amino acid sequence of the core functional region is homologous to native human Type III collagen. It features an active triple‑helix conformation and contains no animal‑derived impurities.
What is the difference between Recombinant Type III Humanized Collagen and Recombinant Type I Humanized Collagen?
Type I collagen consists of thick fibrils with high rigidity, favoring mechanical tissue support. It is widely used as raw material for bone scaffolds and deep-support medical devices. Type III collagen adopts a flexible network structure with excellent cell affinity, suitable for manufacturing end products such as wound, mucosa and skin barrier repair products. The two types can be selected and combined according to the registration positioning of final products.
What is the recommended dosage of Recombinant Type III Humanized Collagen?
It serves only as a reference formulation range and can be adjusted based on formulation system and product positioning. 1. Cosmetics (serums, masks, repair lotions): 0.02%–0.5% (w/w); 0.1%–0.5% is recommended for high-activity lyophilized powder. 2. Class II wound dressings: 0.1%–5%. 3. Class III injectable medical devices: Follow the registered formulation of products (2~16 mg/mL). It is recommended to add the raw material below 45°C to prevent high-temperature denaturation of protein.
What are the storage conditions and packaging specifications for Recombinant Type III Humanized Collagen?
Store hermetically protected from light at 2~8°C under refrigeration. Standard packaging specifications: 10 g/bottle, 100 g/bottle, 1 kg/bottle; small-batch aliquot service available. Cold chain transportation is recommended; avoid prolonged exposure at ambient temperature.