CaHA（Calcium‑Hydroxylapatite）Calcium Hydroxyapatite
CaHA is commonly used for substrate R&D in soft tissue augmentation and bone repair. Confirm end application, microsphere particle size, spherical morphology and packaging specifications prior to purchase. Xi'an Wanlv is available to negotiate supply limits, batch documents and samples.
Overview
Why is Hydroxyapatite gaining increasing popularity?
Hydroxyapatite, also known as hydroxylapatite, is a natural mineral form of calcium apatite with the formula Ca5(PO4)3(OH). It is often written as Ca10(PO4)6(OH)2 to represent its crystal structure consisting of two formula units. Hydroxyapatite is the pure end-member of apatite containing hydroxide ions.
The OH- ions can be substituted by fluoride, chloride or carbonate ions to form fluorapatite or chlorapatite. As a bioactive material composed of calcium and phosphorus, hydroxyapatite is the native inorganic component found in human bones and teeth, granting it inherent advantages in biomedical applications. Professionals engaged in oral care, medical materials and bioceramics frequently work with hydroxyapatite. Its English name is Hydroxyapatite, commonly abbreviated as HAP in the industry, with CAS No. 1306-06-5. Essentially, it is a high-purity calcium phosphate mineral and one of the core inorganic constituents of human bone and tooth enamel. In other words, it is not a newly artificially invented material; it naturally exists within the human body. This explains its rising attention in toothpaste, medical implantation, bone repair, cosmetics and functional coating industries in recent years.
What can Wanlu supply?
Wanlu provides stable, diversified-specification hydroxyapatite products. We deliver targeted material support tailored to different project requirements to help customers improve R&D efficiency and application conversion capability.
Learn more:Calcium-Hydroxylapatite (CaHA): A Bioceramic Substrate for Implantable Medical Devices
Hydroxyapatite HAP/CaHA Powder: Morphology and Particle Size Determine Application Performance
Hydroxyapatite: What’s the Difference Between HAP and CaHA, and How to Choose?
Popular Regenerative Materials in Aesthetic Medicine: CaHA, PLLA, PDLLA, PCL
Figure 1 SEM image of porous microspheres
Figure 2 SEM image of microporous microspheres
Figure 3 SEM image of solid microspheres
Key Parameters
Applications
Soft Tissue Regeneration Research
CaHA hydroxyapatite microspheres can be applied in formulation development of regenerative gel carriers. Relevant academic research focuses on fundamental exploration of soft tissue regeneration and contour remodeling. This raw material shall not be injected into human body directly. Downstream commercialization requires completion of medical device registration and approval in accordance with regulations.
Bone Tissue Engineering R&D
Applicable to formulation development of bone tissue engineering scaffolds and artificial joint coatings. The material exhibits osteoconductive material properties. Relevant research focuses on fundamental studies of bone defects. It cannot be directly used as bone repair implant devices.
Dental Material R&D
Suitable for formulation development of dental implant coatings and oral restorative materials. Basic experimental research is carried out on regeneration of alveolar bone and dentin. Downstream products can only be used clinically after completing medical device compliance registration.
Carrier Material Research
Porous CaHA can serve as a carrier substrate for laboratory fundamental research on loading of small-molecule drugs and nucleic acids, as well as sustained-release systems. It does not function as pharmaceutical or gene therapy formulations and shall not be directly used for human drug delivery and treatment.
Biochemical Separation Medium
It can be used as a substrate for chromatographic packing materials for separation and purification research of laboratory biological macromolecule samples (monoclonal antibodies, enzymes, plasmid DNA, vaccine samples).
Scientific Research & Development
We undertake joint development projects with universities, research laboratories and R&D teams. Technical documents and research samples are available upon application. Samples are for laboratory tests only and are prohibited from direct human application without compliance approval.
Product FAQ
What are Calcium Hydroxyapatite Microspheres (CaHA)?
Calcium Hydroxyapatite Microspheres (CaHA) are synthetic calcium‑phosphate bioceramic microspheres. Their chemical composition is highly similar to the inorganic minerals of human bones and teeth. They feature excellent biocompatibility and bioactivity, low immunogenicity and stable physicochemical properties. They are core raw materials in regenerative medicine, tissue engineering and biological dressing sectors.
What is the difference between CaHA microspheres and conventional hydroxyapatite powder?
Conventional hydroxyapatite mostly exists as irregular powder with severe agglomeration and poor dispersibility. Our CaHA are well‑defined microspheres with high sphericity, uniform and controllable particle size, good fluidity and low tendency to agglomerate or settle. With stable specific surface area, they are suitable for precision formulation, scaffold preparation and coating processes, delivering far better performance and stability than ordinary powder raw materials.
What are the key material advantages of calcium hydroxyapatite microspheres?
① High biosafety: chemically close to human natural minerals, good compatibility and low irritation; ② Uniform spherical morphology: narrow particle‑size distribution and stable batch‑to‑batch consistency, suitable for fine‑scale R&D and production; ③ Good ionic activity: capable of slow release of calcium and phosphate ions for tissue‑related material research; ④ Excellent compatibility: can be compounded with polymers, gels and dressing systems without delamination or caking; ⑤ Stable properties: storage‑tolerant and oxidation‑resistant, applicable to diverse formulation development.
What particle‑size ranges are available for CaHA microspheres? Is customization supported?
Standard micron‑size ranges are in regular supply, featuring intact spherical shape and narrow particle‑size distribution. Customization is available for particle size, pore structure and Ca/P ratio. Dense or porous microspheres can be tailored to meet experimental and production requirements, with corresponding particle‑size test data provided.
What are the application differences between porous CaHA microspheres and solid CaHA microspheres?
Solid microspheres deliver higher sphericity, superior fluidity and homogeneous dispersion, ideal for precision formulations, dressing coating and composite‑system modification. Porous microspheres possess abundant pore structures and large specific surface area, suited for cell attachment, drug loading, tissue‑engineering scaffolds and adsorptive biomaterial research. Selection can be made according to customer application scenarios.
What are the main application fields of calcium hydroxyapatite microspheres?
Qualified raw‑material applications include tissue‑engineering scaffold R&D, bone‑repair biomaterials, regenerative‑medicine research, wound‑dressing raw materials, biological carrier materials, biomedical formulations, university laboratory research and bioceramic composite development. This product is a basic raw material, not an injectable aesthetic finished product, and shall not be used for clinical injection therapy.